Effect of Ethanolic Extract of Seeds of Solanum torvum in Acetic Acid induced Ulcerative Colitis in Male Wistar Rats

Objective: To elucidate the protective effect of ethanolic extract of dried seeds of Solanum torvum (S. torvum) in acetic acid-induced ulcerative colitis in male Wistar rats. Methods: The animals were divided into various treatment groups (n=5). Rats were administered with 2ml of acetic acid (4%) via intrarectal route. Prednisolone was used as a standard drug and S. torvum was administered at a dose of 100 and 300mg/kg, p.o. Macroscopic score, colon weight to length ratio, colonic superoxide dismutase (SOD), reduced glutathione (GSH), myeloperoxidase (MPO), catalase (CAT), and lipid peroxidation (TBARS) levels and histopathological changes were recorded after the treatment regimen of 11 days.Results: Intrarectal instillation of acetic acid caused significant (