Advanced mapping techniques in contemporary management of ventricular arrhythmias:unmasking the arrhythmic substrate

Both prophylactic ICD implantation and catheter ablation have important therapeutic implications in contemporary management of patients with lifetreatening rhythm disorders after myocardial infarction, originating from an arhrythmic substrate from a scarred area. According to the longterm results of the DAPA trial, prophylactic implantation of an implantable cardioverter defibrillator in patients with an acute myocardial infarction undergoing percutanous coronary intervention, reduced the risk for death in certain high-risk patients. This study underlined that we need to be careful extrapolating evidence of aging literature on a contemporary population. Other development of novel technologies in the field of catheter ablation, also asks for development of our view on the intended use of these strategies. Especially for specific cardiac diseases due to genetic mutations (Brugada syndrome and PLN mutants), there is not a one-size fits all manner for catheter based ablation and a disease-specific approach is mandatory for successful treatment. This thesis has shown that electro-anatomic mapping may be of significant value for a more complete definition and understanding of the arrhythmic substrate