Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study (GWAS) data from 2,535,601 individuals (39.7% non-European ancestry), including 428,452 T2D cases. We identify 1,289 independent association signals at genome-wide significance (P<5×10 - 8 ) that map to 611 loci, of which 145 loci are previously unreported. We define eight non-overlapping clusters of T2D signals characterised by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type specific regions of open chromatin, including pancreatic islets, a...
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 d...
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent...
The genetic architecture of common traits, including the number, frequency, and effect sizes of inhe...
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological pr...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we ...
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-ana...
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date...
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 d...
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent...
The genetic architecture of common traits, including the number, frequency, and effect sizes of inhe...
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological pr...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we ...
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-ana...
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date...
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 d...
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent...
The genetic architecture of common traits, including the number, frequency, and effect sizes of inhe...