The role of secretory and inflammatory cells in nasal and paranasal hypersecretion

1)慢性副鼻腔炎では上顎洞,下甲介粘膜とも杯細胞の増生はなく,杯細胞が本症の鼻汁産生に重要な役割を果たしていない。2)慢性副鼻腔炎では上顎洞,下甲介粘膜ともに固有層の腺細胞の増生と肥大をみとめ,本症の鼻汁産生に上顎洞および固有鼻腔の腺細胞が重要な役割を果たしている。3)鼻アレルギー下甲介粘膜においても腺細胞の増生と肥大が認められたが,杯細胞の増生はなかったNasal mucosae were obtained from inferior turbinate of normal adults (N) , adults patients with chronic sinusitis (CS) and adults patients with allergic rhinitis (AR) . Maxillary mucosae were also obtained from N and CS patients during sinus surgery. Our quantitative histochemical study shows that no significant difference was observed in the number of goblet cells between groups N, CS and AR in nasal mucosa. and between groups N and CS in maxillary mucosa. The number of submucosal gland cells (SGC) of nasal mucosa in CS and AR was significantly increased compared with that in N. The similar significant increase was founding the SGC of maxillary mucosa of CS. Moreover , the area occupied by SGC in submucosa was significantly increased in both nasal mucosa and in maxillary mucosa of the patients. Our results suggest that both hyperplasia and hypertrophy of submucosal glands could be a major factor of hypersecretion in CS and AR. A cause of hyperplasia and hypertrophy of the glands was discussed in relation to inflammatory cells