Incidence od malignant diseases in patients with systemic lupus erythematosus in Zadar county

CILJ ISTRAŽIVANJA: Cilj ovog istraživanja bio je utvrditi incidenciju malignih oboljenja u bolesnika sa SLE-om u Zadarskoj županiji u 15-godišnjem periodu (od 2007.-2022. godine.) MATERIJALI I METODE; Istraživanje je obuhvatilo 144 bolesnika sa SLE-om liječenih u razdoblju od 2007.-2022. godine te je provedeno pretraživanjem elektronske baze podataka Opće bolnice Zadar. REZULTATI: Od 144 bolesnika sa SLE-om, 126 je bilo ženskog spola (87.50%), a 18 muškog spola (12.50%). Od 12 bolesnika sa SLE-om i malignim oboljenjem, 2 su bila muškarca (16.70%), a 10 žena (83,30%). Prosječna dob bolesnika sa SLE-om bila je 53 godine, a bolesnika sa SLE-om i malignim oboljenjem 61 godina. Sveukupno je pronađeno 14 malignih tumora jer su neki bolesnici imali više od jednog tumora. Većina bolesnika (91.70%) je oboljela od malignog tumora nakon postavljanja dijagnoze SLE-a. Najčešće lokalizacije malignoma bile su dojka, kolon, koža te maternica. Troje bolesnika iz skupine s malignim oboljenjima je preminulo od posljedica malignoma. ZAKLJUČAK: Maligno oboljenje se javilo u 8.83% bolesnika s dijagnozom SLE-a. Prosječna dob bolesnika s malignim oboljenjima u sklopu SLE-a je nešto veća nego kod bolesnika bez malignih oboljenja. Najčešće lokalizacije malignoma bile su dojka, kolon, koža te maternica.OBJECTIVES: The aim of this study was to determine the incidence of malignant diseases in patients with SLE in the Zadar County in a 15-year period (from 2007 to 2022). MATERIALS AND METHODS; The research included 144 patients with SLE treated in the period from 2007 to 2022. and was conducted by searching the electronic database of the Zadar General Hospital. RESULTS: Out of 144 patients with SLE, 126 were female (87.50%) and 18 were male (12.50%). Out of 12 patients with SLE and malignant disease, 2 were men (16.70%) and 10 were women (83.30%). The average age of patients with SLE was 53 years and the average age of patients with SLE and malignant disease was 61 years. A total of 14 malignant tumors were found, as some patients had more than one tumor. The majority of patients (91.70%) suffered from a malignant tumor after the diagnosis of SLE. The most common localizations of malignant tumors were breast, colon, skin and mother. Three patients from the group with malignant diseases died as a result of malignant tumors. CONCLUSION: Malignant disease occurred in 8.83% of patients diagnosed with SLE. The average age of patients with malignant diseases in SLE is slightly higher than in patients without malignant diseases. The most common localizations of malignant tumors were breast, colon, skin and uterus