International audienceBackground: Studies showed the impact of sex and onset site (spinal or bulbar) on disease onset and survival in ALS. However, they mainly result from cross-sectional or survival analysis, and the interaction of sex and onset site on the different proxies of disease trajectory has not been fully investigated. Methods: We selected all patients with repeated observations in the PRO-ACT database. We divided them into four groups depending on their sex and onset site. We estimated a multivariate disease progression model, named ALS Course Map, to investigate the combined temporal changes of the four sub-scores of the revised ALS Functional Rating Scale (ALSFRSr), the forced vital capacity (FVC), and the body mass index (BMI...
We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, ...
Objective: The lack of prognostic biomarkers in patients with amyotrophic lateral sclerosis (ALS) in...
Objectives and Methods: Using pooled multivariable-adjusted rate ratios (RR), we explored relationsh...
International audienceObjectives: Amyotrophic lateral sclerosis (ALS) is a rare disease with heterog...
We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, ...
International audienceObjective: To assess time-trend evolution and determinants of sex ratio (SR) i...
Introduction: The C9orf72 repeat expansion has been reported as a negative prognostic factor in amyo...
INTRODUCTION: The C9orf72 repeat expansion has been reported as a negative prognostic factor in amyo...
We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no known cure. Approxi...
Background: Amytrophic lateral sclerosis (ALS) is a fatal neurologic disease that is projected to do...
International audienceBackground: A noticeable change of the male-to-female sex ratio (SR) has been...
We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, ...
Objective: The lack of prognostic biomarkers in patients with amyotrophic lateral sclerosis (ALS) in...
Objectives and Methods: Using pooled multivariable-adjusted rate ratios (RR), we explored relationsh...
International audienceObjectives: Amyotrophic lateral sclerosis (ALS) is a rare disease with heterog...
We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, ...
International audienceObjective: To assess time-trend evolution and determinants of sex ratio (SR) i...
Introduction: The C9orf72 repeat expansion has been reported as a negative prognostic factor in amyo...
INTRODUCTION: The C9orf72 repeat expansion has been reported as a negative prognostic factor in amyo...
We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no known cure. Approxi...
Background: Amytrophic lateral sclerosis (ALS) is a fatal neurologic disease that is projected to do...
International audienceBackground: A noticeable change of the male-to-female sex ratio (SR) has been...
We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, ...
Objective: The lack of prognostic biomarkers in patients with amyotrophic lateral sclerosis (ALS) in...
Objectives and Methods: Using pooled multivariable-adjusted rate ratios (RR), we explored relationsh...