Indole-Based Compounds as Promising Inhibitors of SARS-CoV-2

This review focused on the recent development of indole-based compounds as anti- SARS-CoV-2 agents with focus on the following objectives: 1) present the design strategy of indole-based compounds as promising inhibitors; 2) focus on recent developments of indole-based compounds and their anti-severe acute respiratory syndrome coronavirus 2 and anti-severe acute respiratory syndrome coronavirus activities; 3) summarize molecular docking and the structure–activity relationship, in hopes to inspire the development of new and more creative approaches; and 4) offer perspectives on how indole scaffolds might be exploited in the future