Technological change and digitalization have enabled a wave of multi-sided platform markets where network externalities, big data and algorithmic matching contribute to concentrated market structures and monopolistic tendencies. Yet the assessment of conditions under which such tendencies may be natural and efficient remains underdeveloped, and the consequential determination of the appropriate regulatory tools and institutions associated with natural concentration unexplored. This thesis evaluates the applicability of the natural monopoly framework to three case studies of platform markets: horizontal search engines, e-commerce marketplaces, and ride-hailing platforms. It demonstrates that technological change and the increasing predominan...