Does the Local Application of Teriparatide Prevent Medication-related Osteonecrosis of the Jaw after Tooth Extraction in Rats?

Systemic Teriparatide treatment in patients with medication-related osteonecrosis of the jaw (MRONJ) has shown promising results in clinical studies. I hypothesized that local application of PTH (1-34) on an acellular collagen sponge (ACS) following tooth extraction would lower the incidence of MRONJ. In rat model of MRONJ, the maxillary molars were extracted then the extraction sockets were filled with ACS+PTH (1-34), ACS or left unfilled. The extraction sites were assessed clinically for bone exposure, and then underwent analysis by microCT and histology. The ACS+PTH (1-34) group had a significantly lower incidence of bone exposure and less exposed bone area (0. pM.Sc