Muscular contraction frequency does not affect plasma homocysteine concentration in response to energy expenditure and intensity matched acute exercise in sedentary males

Acute exercise seems to increase total plasma homocysteine (tHcy). That is related to cardiovascular risk, therefore it is important to understand the determinants of its response to all types of exercise. The aim of this study was to examine the impact of cycling at two different rates of muscle contraction on the complete tHcy kinetics. Eight young sedentary males were required to complete two isocaloric (400 kcal) acute exercise trials at 50% VO2peak on separate occasions at 50 or 80 revolutions per minute (rpm). Blood samples were drawn at different points before (pre4 and pre0 h), during (exer10, exer20, exer30, exer45, and exer60 min), and after exercise (post0 and post19 h). Dietary and lifestyle factors were controlled during the research. Maximum tHcy occurred during exercise, for both conditions (50 rpm: 11.4 ± 2.7 µmol/L; 80 rpm: 10.8 ± 3.2 µmol/L). From this point onwards tHcy declined until the cessation of exercise and continued descending below pre exercise values at 19h post exercise (pThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author