Sirt6 has been reported to play a protective role in macrophage foam cell formation, but whether Sirt6 controls atherosclerosis plaque stability and whether it can reduce the interaction between endothelial cells and macrophages remains obscure. The aim of this study was to investigate the effect of Sirt6 on atherosclerosis plaque stability and the underlying mechanisms. We used Tie2-Cre transgenic mice as a Cre-lox tool to delete Sirt6 floxed sequences in endothelial cells during adulthood to establish Sirt6-/- mice. ApoE-/-:Sirt6-/- and ApoE-/-:Sirt6Tg mice were used in our investigation. After a 16-week high-fat diet, the mice developed markedly atherosclerotic plaques. Sirt6 knockout exacerbated atherosclerotic plaque progression in bot...
Abstract—Evidence is accumulating that autophagy occurs in advanced atherosclerotic plaques. Althoug...
Background : Previous studies implicated Toll-like receptor signaling as a critical pathogenic pathw...
Background-Previous studies implicated Toll-like receptor signaling as a critical pathogenic pathway...
Sirt6 has been reported to play a protective role in macrophage foam cell formation, but whether Sir...
Abstract Lipid metabolism disorders are considerably involved in the pathology of atherosclerosis; n...
SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, th...
Aims: Sirtuin 6 (Sirt6) is a NAD(+)-dependent deacetylase that plays a key role in DNA repair, infla...
Endothelial activation, macrophage infiltration, and foam cell formation are pivotal steps in athero...
Macrophage infiltration contributes to the instability of atherosclerotic plaques. In the present st...
Foam cell formation and macrophage polarization are involved in the pathologic development of athero...
The growth arrest-specific gene 6 (Gas6) plays a role in pro-atherogenic processes such as endotheli...
Aims Hazardous environmental and genetic factors can damage endothelial cells to induce atherosclero...
A prominent feature of inflammatory diseases is endothelial dysfunction. Factors associated with end...
RATIONALE: The mammalian target of rapamycin complex 1 inhibitor, rapamycin, has been shown to decre...
Atherosclerosis is a chronic inflammatory disorder of the large arteries and represents the primary ...
Abstract—Evidence is accumulating that autophagy occurs in advanced atherosclerotic plaques. Althoug...
Background : Previous studies implicated Toll-like receptor signaling as a critical pathogenic pathw...
Background-Previous studies implicated Toll-like receptor signaling as a critical pathogenic pathway...
Sirt6 has been reported to play a protective role in macrophage foam cell formation, but whether Sir...
Abstract Lipid metabolism disorders are considerably involved in the pathology of atherosclerosis; n...
SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, th...
Aims: Sirtuin 6 (Sirt6) is a NAD(+)-dependent deacetylase that plays a key role in DNA repair, infla...
Endothelial activation, macrophage infiltration, and foam cell formation are pivotal steps in athero...
Macrophage infiltration contributes to the instability of atherosclerotic plaques. In the present st...
Foam cell formation and macrophage polarization are involved in the pathologic development of athero...
The growth arrest-specific gene 6 (Gas6) plays a role in pro-atherogenic processes such as endotheli...
Aims Hazardous environmental and genetic factors can damage endothelial cells to induce atherosclero...
A prominent feature of inflammatory diseases is endothelial dysfunction. Factors associated with end...
RATIONALE: The mammalian target of rapamycin complex 1 inhibitor, rapamycin, has been shown to decre...
Atherosclerosis is a chronic inflammatory disorder of the large arteries and represents the primary ...
Abstract—Evidence is accumulating that autophagy occurs in advanced atherosclerotic plaques. Althoug...
Background : Previous studies implicated Toll-like receptor signaling as a critical pathogenic pathw...
Background-Previous studies implicated Toll-like receptor signaling as a critical pathogenic pathway...