CLINICAL CHARACTERISTICS AND OUTCOMES IN PATIENTS WITH INFECTIVE ENDOCARDITIS (IE)

Infective endocarditis (IE) is a serious medical condition with significant morbidity and mortality. We sought to determine the clinical characteristics, microbiological profile and long-term outcome of IE patients at a tertiary care Canadian hospital. A total of 307 confirmed IE cases were included from, January 2008 to June 2016. The mean age of study population was 58 ±16 years, including 66% males. A native cardiac valve (NVE) was affected in 238 patients (77.5%) and Staphylococcus aureus was isolated in 98 cases (32%). Surgery was performed in 190 patients (61.8%), with 120 early surgeries (63%) during index hospitalization. At a median follow up of 235 days (IQR 45-1012 days), 90 patients had died (29%); 44.4% from medical and 20% from surgical cohort, p=0.001. On multivariate analysis, age (OR 1.04 95%CI 1.02-1.07, p=0.000), heart failure (OR 3.62 95%CI 1.06-12.41, p=0.04) and septic shock (OR 2.89 95%CI 1.18-7.08, p=0.02) were predictors of mortality.M.Sc