A Moderate In Vivo Lengthening Contraction Protocol Caused Muscle Damage in Mdx Mice

Duchenne muscular dystrophy is a severe muscle wasting disease caused by the failure to produce dystrophin. Dystrophic mdx and healthy C57 mice (n=5/group/time point) were subject to 15 stimulated, in vivo lengthening contractions and examined following 0, 3, or 24 hours to determine if the severe dystrophic response to exercise could be reproduced with a moderate volume of contractions. As expected, the mdx mice exhibited greater force loss (pM.Sc