Transcriptional profile of muscle following acute induction of symptoms in a mouse model of Kennedy's disease/spinobulbar muscular atrophy

This is an accepted manuscript published by the Public Library of Science.Kennedy’s disease/Spinobulbar muscular atrophy (KD/SBMA) is a degenerative neuromuscular disease affecting males. This disease is caused by polyglutamine expansion mutations of the androgen receptor (AR) gene. Although KD/SBMA has been traditionally considered a motor neuron disease, emerging evidence points to a central etiological role of muscle. We previously reported a microarray study of genes differentially expressed in muscle of three genetically unique mouse models of KD/SBMA but were unable to detect those which are androgen-dependent or are associated with onset of symptoms.The work reported in this manuscript received financial support from the Canadian Institutes of Health Research (CIHR www.cihr-irsc.gc.ca) Operating Grant JNM-116637 (DAM) and Natural Sciences and Engineering Research Council of Canada (NSERC - www.nserc-crsng.gc.ca) Discovery Grant RGPIN 312458 (DAM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript