The widely studied HSPA1A is a heat shock protein that counters the effects of protein misfolding. The little studied HSPA6 is present in the human genome and absent in mouse and rat, hence missing in current models of neurodegenerative diseases. Differentiated human neuronal SH-SY5Y cells were used to compare the dynamics of the association of YFP-tagged HSPA6 and HSPA1A with stress-sensitive sites by employing Fluorescence Recovery After Photobleaching (FRAP). Following thermal stress, HSPA6 displayed a prolonged and more dynamic association, compared to HSPA1A, with centrioles that play critical roles in neuronal polarity and migration. HSPA6 and HSPA1A displayed similar FRAP kinetics with nuclear speckles and the nucleolus. Subsequently...
The small heat shock proteins (sHSP) comprise 10 members in mammals where they are called the HspB p...
Heat shock protein Hsp70 is known to play an important role in cell protection against a variety of ...
By means of confocal laser scanning microscopy and indirect fluorescence experiments we have examine...
Heat shock proteins (Hsps) are a set of highly conserved proteins that are involved in cellular repa...
Heat shock proteins (Hsps) are a set of conserved proteins involved in cellular repair and protectio...
Heat shock proteins (Hsps) are protein repair agents that detect and refold misfolded proteins and p...
Heat shock protein HSPA8 (Hsc70) is a constitutively expressed member of the Hsp70 multigene family ...
Heat shock proteins (Hsps) represent the most evolutionarily ancient, conserved, and universal syste...
Heat-shock proteins are induced in response to cellular stress. Although heat-shock proteins are kno...
Causes of lower induction of Hsp70 in neurons during heat shock are still a matter of debate. To fur...
grantor: University of TorontoThis thesis examines the expression of heat shock proteins ...
Heat induces Hsp70.1 (HSPA1) and Hsc70 (HSPA8) to form complex detergent insoluble cytoplasmic and n...
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerat...
In response to many environmental and pathophysiologic stressful stimuli, cells undergo a stress res...
International audienceThe nuclear translocation of endogenous heat shock cognate protein HSPA8 is a ...
The small heat shock proteins (sHSP) comprise 10 members in mammals where they are called the HspB p...
Heat shock protein Hsp70 is known to play an important role in cell protection against a variety of ...
By means of confocal laser scanning microscopy and indirect fluorescence experiments we have examine...
Heat shock proteins (Hsps) are a set of highly conserved proteins that are involved in cellular repa...
Heat shock proteins (Hsps) are a set of conserved proteins involved in cellular repair and protectio...
Heat shock proteins (Hsps) are protein repair agents that detect and refold misfolded proteins and p...
Heat shock protein HSPA8 (Hsc70) is a constitutively expressed member of the Hsp70 multigene family ...
Heat shock proteins (Hsps) represent the most evolutionarily ancient, conserved, and universal syste...
Heat-shock proteins are induced in response to cellular stress. Although heat-shock proteins are kno...
Causes of lower induction of Hsp70 in neurons during heat shock are still a matter of debate. To fur...
grantor: University of TorontoThis thesis examines the expression of heat shock proteins ...
Heat induces Hsp70.1 (HSPA1) and Hsc70 (HSPA8) to form complex detergent insoluble cytoplasmic and n...
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerat...
In response to many environmental and pathophysiologic stressful stimuli, cells undergo a stress res...
International audienceThe nuclear translocation of endogenous heat shock cognate protein HSPA8 is a ...
The small heat shock proteins (sHSP) comprise 10 members in mammals where they are called the HspB p...
Heat shock protein Hsp70 is known to play an important role in cell protection against a variety of ...
By means of confocal laser scanning microscopy and indirect fluorescence experiments we have examine...