Delineating a Metabolomic Signature for the Transition from Gestational Diabetes to Type 2 Diabetes

Although gestational diabetes (GDM) is of a transient nature, up to 50% of women with GDM develop type 2 diabetes (T2D) within 5 years. Despite this extremely high risk, post-partum screening remains low. Here, we delineated a predictive metabolomic signature of disease transition. The study patients were part of the SWIFT Cohort, which follows 1010 GDM women, 109 of which developed T2D two years post-partum. Future cases were matched to future controls based on ethnicity, age and pre-pregnancy BMI. Hexoses, specific amino acids, specific sphingomyelin and specific phosphatidylcholine species associated with T2D. Through a J48 decision tree predictive modelling in the training set, future T2D incidence was predicted in an independent testing set with discriminative power 0.769 (PM.Sc.2017-01-12 00:00:0