Behavioural Effects Of The Methanolic Root Bark Extract Of Securinega Virosa In Rodents

Securinega Virosa is used traditionally as sedative in children and in mental illnesses. In this study, the behavioral effects of methanolic root bark extract of S. virosa were investigated in mice. The results revealed that the extract significantly (P<0.05) and dose-dependently reduced the onset and prolonged the duration of sleep. The extract significantly (P<0.05) decreased exploratory activity and reduced the rate of apomorphine-induced stereotyped climbing at the doses tested (6.25-25mg/kg). It also produced a significant and dose-dependent motor coordination deficit in mice at the doses tested (P