Pharmacological Evaluation of a Nigerian Polyherbal Health Tonic Tea in Rat

The present study is a fourteen day study, designed to investigate the hematological and biochemical effects of single, daily oral doses of 100 – 600 mg/kg of a Nigerian Polyherbal Tonic Tea (PHT) in four groups of adult Wistar rats. Acute oral toxicity test of PHT at the limit dose of 5000 mg/kg was also conducted using Up-and-Down Procedure on statistical software program (AOT425StatPgm, Version 1.0.). Results showed PHT to induce significant (p<0.05) dose-related elevation in the packed cell volume (PCV), platelet, total leukocyte counts and lymphocyte differentials, while causing significant (p<0.05) suppression of granulocyte differentials in dose-related fashion. PHT, also, induced a significant (p