Central to Leibniz's philosophical system is his view that substances must have genuine unity, that they must be simple or indivisible. In this dissertation, I argue that Leibniz's well-known view that substances must be simple, i.e. without parts, follows from his commitment to mereological nihilism--the view that nothing with a plurality of parts is truly one being. I begin by offering a detailed analysis of Leibniz's view that matter or body is inherently plural. I argue that the reasons for this view have not been fully understood, and are rooted in Leibniz's claim that matter is discrete. I then defend Leibniz's commitment to the plurality of matter against what I call the 'Spinozistic Challenge' according to which the entire physical ...