Add to ORKGAutism and associated gene mutations can be studied with genetic mouse models. Magnetic Resonance Imaging (MRI) of these animal models quantifies the impact of genetics on brain morphology. Using MRI, three genetic mouse models of autism were imaged: Neuroligin 3 R451C knock-in, Methyl-CpG binding protein-2 308-truncation and Integrin β-3 knock-out. Morphological differences were identified using a newly developed MRI mouse cerebellum atlas. The results show all three genes to alter cerebellar anatomy. Each studied gene affected a unique set of cerebellar structures. I hypothesize that the results and known behavioural phenotypes of the models are linked, with anatomy contributing to specific behaviours. In the future work section, a surfac...
Background: Autism spectrum disorders (ASD) are a group of poorly understood behavioural disorders, ...
Abstract Background There is interest in defining mouse neurobiological phenotypes useful for studyi...
Research efforts over the past decades have unraveled both genetic and environmental factors, which ...
Autism and associated gene mutations can be studied with genetic mouse models. Magnetic Resonance Im...
In order to understand the consequences of the mutation on behavioral and biological phenotypes rele...
Autism is a heritable disorder, with over 250 associated genes identified to date, yet no single gen...
Autism is a heritable disorder, with over 250 associated genes identified to date, yet no single gen...
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by disturban...
(BTBR) strain, exhibiting fully penetrant AgCC, a diminished hippocampal commissure, and abnormal b...
BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining symptoms of...
BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining symptoms of...
Objective: To explore the relationship between cerebellar pathology and changes in neuronal activity...
<div><p>BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining sym...
Research efforts over the past decades have unraveled both genetic and environmental factors, which ...
Research efforts over the past decades have unraveled both genetic and environmental factors, which ...
Background: Autism spectrum disorders (ASD) are a group of poorly understood behavioural disorders, ...
Abstract Background There is interest in defining mouse neurobiological phenotypes useful for studyi...
Research efforts over the past decades have unraveled both genetic and environmental factors, which ...
Autism and associated gene mutations can be studied with genetic mouse models. Magnetic Resonance Im...
In order to understand the consequences of the mutation on behavioral and biological phenotypes rele...
Autism is a heritable disorder, with over 250 associated genes identified to date, yet no single gen...
Autism is a heritable disorder, with over 250 associated genes identified to date, yet no single gen...
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by disturban...
(BTBR) strain, exhibiting fully penetrant AgCC, a diminished hippocampal commissure, and abnormal b...
BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining symptoms of...
BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining symptoms of...
Objective: To explore the relationship between cerebellar pathology and changes in neuronal activity...
<div><p>BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining sym...
Research efforts over the past decades have unraveled both genetic and environmental factors, which ...
Research efforts over the past decades have unraveled both genetic and environmental factors, which ...
Background: Autism spectrum disorders (ASD) are a group of poorly understood behavioural disorders, ...
Abstract Background There is interest in defining mouse neurobiological phenotypes useful for studyi...
Research efforts over the past decades have unraveled both genetic and environmental factors, which ...