Cerebral perfusion is optimized during hemodilution by both β1- and β2-adrenergic mechanisms. Antagonism of the β2-adrenoreceptor can impair cerebral vasodilation. We hypothesized that treatment with a highly β1-specific antagonist (nebivolol) would minimize the degree of cerebral hypoxia during hemodilution. Anesthetized rats were randomized to receive vehicle or nebivolol (1.25 or 2.5 mg/kg intravenously) prior to hemodilution. In vehicle-treated rats, hemodilution increased cardiac output (CO) and regional cerebral blood flow (rCBF) while microvascular brain PO2 (PBrO2) decreased. Both nebivolol doses reduced heart rate and attenuated the CO response to hemodilution. Only the higher dose of nebivolol attenuated the rCBF response to hemod...
AbstractHypertension induces left-ventricular hypertrophy (LVH) by mechanisms involving oxidative st...
Purpose: We evaluated the effects of beta-adrenoceptor agonists on detrusor hyperreflexia in cerebra...
lution during cerebral ischemia reduce brain injury and edema. Am. J. Physiol. 259 (Heart Circ. Phys...
Cerebral perfusion is optimized during hemodilution by both β1- and β2-adrenergic mechanisms. Antago...
BACKGROUND: Acute β-blockade has been associated with a dose-dependent increase in adverse outcomes,...
Background. Haemodilution has been associated with neurological morbidity in surgical patients. This...
BACKGROUND:: Perioperative β-blockade and anemia are independent predictors of increased stroke and ...
In the pithed rat we investigated the cardiovascular properties of d,l-nebivolol and its enantiomers...
Nebivolol is known to have beta-1 blocker activity, but it was also suggested that it elicits relaxa...
Background: Maintenance of brain circulation during shock is sufficient to prevent subcortical injur...
RATIONALE: Nebivolol is known to have beta-1 blocker activity, but it was also suggested that it eli...
While the cerebral autoregulation sufficiently protects subcortical brain regions during hypoxia or ...
© 2015 Dr. Yohannes Ayele MamoThe brain receives a tightly controlled blood flow that maintains its ...
The importance of chronic stimulation of β-adrenoceptors in the development of cardiac dysfunction i...
<p>The role of beta1-adrenoreceptors at visual associative cortex in rats of different age in the im...
AbstractHypertension induces left-ventricular hypertrophy (LVH) by mechanisms involving oxidative st...
Purpose: We evaluated the effects of beta-adrenoceptor agonists on detrusor hyperreflexia in cerebra...
lution during cerebral ischemia reduce brain injury and edema. Am. J. Physiol. 259 (Heart Circ. Phys...
Cerebral perfusion is optimized during hemodilution by both β1- and β2-adrenergic mechanisms. Antago...
BACKGROUND: Acute β-blockade has been associated with a dose-dependent increase in adverse outcomes,...
Background. Haemodilution has been associated with neurological morbidity in surgical patients. This...
BACKGROUND:: Perioperative β-blockade and anemia are independent predictors of increased stroke and ...
In the pithed rat we investigated the cardiovascular properties of d,l-nebivolol and its enantiomers...
Nebivolol is known to have beta-1 blocker activity, but it was also suggested that it elicits relaxa...
Background: Maintenance of brain circulation during shock is sufficient to prevent subcortical injur...
RATIONALE: Nebivolol is known to have beta-1 blocker activity, but it was also suggested that it eli...
While the cerebral autoregulation sufficiently protects subcortical brain regions during hypoxia or ...
© 2015 Dr. Yohannes Ayele MamoThe brain receives a tightly controlled blood flow that maintains its ...
The importance of chronic stimulation of β-adrenoceptors in the development of cardiac dysfunction i...
<p>The role of beta1-adrenoreceptors at visual associative cortex in rats of different age in the im...
AbstractHypertension induces left-ventricular hypertrophy (LVH) by mechanisms involving oxidative st...
Purpose: We evaluated the effects of beta-adrenoceptor agonists on detrusor hyperreflexia in cerebra...
lution during cerebral ischemia reduce brain injury and edema. Am. J. Physiol. 259 (Heart Circ. Phys...