Production of therapeutic proteins in yeasts: A review

Australasian Biotechnology, Volume 6 Number 4, July/August 1996,pp.230-237 Production of therapeutic proteins in yeasts: A review Prasad Rallabhandi and Pak-Lam Yu, Code Number: AU96009 Size of Files: Text: 40.4K Graphics: No associated graphics files ABSTRACT This paper reviews the use of yeasts in the production of heterologous proteins with a special focus on therapeutic proteins. Yeast offers a number of advantages as an expression system over prokaryotic systems. Yeasts are eukaryotic in nature with consequent associated cellular processes such as protein secretion and post-translational modification of proteins to render the recombinant proteins biologically active. This is essential for the naturally secreted therapeutic proteins. With the combination of recombinant techniques and fermentation technology, it is possible to explore yeasts as hosts for the expression and secretion of medically important proteins. Copyright 1996 Australian Biotechnology Association Ltd