Molecular genetics and biotechnology of methylotrophic yeasts

Biotecnologia Aplicada 1996 Volume 13 No. 3, p.203 Molecular genetics and biotechnology of methylotrophic yeasts Cornelis P Hollenberg Code Number:BA96081 Size of Files: Text: 2.9K Graphics: No associated graphics files In recent years an number of yeast species other than Saccharomyces cerevisiae have become accessible for molecular genetics and thereby for potential application in biotechnology. In this respect the methylotrophic yeasts, Hansenula polymorpha and Pichia stipitis have already been proven to offer significant advantages over S. cerevisiae for the production of certain heterologous proteins. The methylotrophic yeasts share general pathways to assimilate and catabolize methanol. Growth on methanol is accompanied by a strong induction of peroxisomes and enzymes involved in methanol metabolism. The strong inducible promoters of the corresponding genes are used for the expression of heterologous genes. Copyright 1996 Elfos Scientia