The immune system recognizes and eliminates an enormous array of pathogens due to the diverse antigen receptor repertoire of T and B lymphocytes. However, the development of lymphocytes bearing receptors with unique specificities requires the generation of programmed double strand breaks (DSB) coupled with bursts of proliferation, rendering lymphocytes susceptible to mutations and oncogenic transformation. Thus, mechanisms responsible for monitoring global genomic integrity, such as those coordinated by the ATM (ataxia-telangiectasia mutated) kinase, must be activated during lymphocyte development to limit the oncogenic potential of antigen receptor locus recombination. I show that ATM deficiency compromises TCRα recombination and the post-...
T lymphoblastic lymphoma/leukemia (T-LL) represent malignant disease of T-cell progenitors. Dysregu...
Cancer onset and progression involves the accumulation of multiple oncogenic hits, which are thought...
SummaryDNA double-strand breaks (DSBs) induce a signal transmitted by the ataxia-telangiectasia muta...
The immune system recognizes and eliminates an enormous array of pathogens due to the diverse antige...
Generation and resolution of DNA double-strand breaks is required to assemble antigen-specific recep...
Lymphocyte development requires the assembly of diversified antigen receptor complexes generated by ...
Generation and resolution of DNA double-strand breaks is required to assemble antigen-specific recep...
The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germlin...
Ataxia telangiectasia (A-T) is a disorder characterized by cerebellar degeneration, immunodeficiency...
The Ataxia Telangiectasia–mutated (ATM) kinase senses DNA double-strand breaks (DSB) and facilitates...
International audienceCancer onset and progression involves the accumulation of multiple oncogenic h...
T lymphoblastic lymphoma/leukemia (T-LL) represent malignant disease of T-cell progenitors. Dysregu...
Cancer onset and progression involves the accumulation of multiple oncogenic hits, which are thought...
SummaryDNA double-strand breaks (DSBs) induce a signal transmitted by the ataxia-telangiectasia muta...
The immune system recognizes and eliminates an enormous array of pathogens due to the diverse antige...
Generation and resolution of DNA double-strand breaks is required to assemble antigen-specific recep...
Lymphocyte development requires the assembly of diversified antigen receptor complexes generated by ...
Generation and resolution of DNA double-strand breaks is required to assemble antigen-specific recep...
The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germlin...
Ataxia telangiectasia (A-T) is a disorder characterized by cerebellar degeneration, immunodeficiency...
The Ataxia Telangiectasia–mutated (ATM) kinase senses DNA double-strand breaks (DSB) and facilitates...
International audienceCancer onset and progression involves the accumulation of multiple oncogenic h...
T lymphoblastic lymphoma/leukemia (T-LL) represent malignant disease of T-cell progenitors. Dysregu...
Cancer onset and progression involves the accumulation of multiple oncogenic hits, which are thought...
SummaryDNA double-strand breaks (DSBs) induce a signal transmitted by the ataxia-telangiectasia muta...