grantor: University of TorontoOne of the pathological consequences of diabetes due to hyperglycemia is the nonenzymatic glycation of free amino groups by glucose. Not only proteins and nucleic acids participate in this reaction but aminophospholipids also under go glycation. This thesis describes the isolation and characterization of the products of the reaction between glucose and amino phospholipids 'in vitro' and 'in vivo' sources and their possible pathogenic effects. The major glycation products described here are the products of phosphatidylethanolamine (PtdEtn) and phosphatidylserine (PtdSer) with glucose which were identified by liquid chromatography with online electrospray mass spectrometry (LC/MS). The major product of ...
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: ple...
Increased oxidative stress is associated with type-2 diabetes and related cardiovascular diseases bu...
People with diabetes experience chronic hyperglycemia and are at a high risk of developing atheroscl...
grantor: University of TorontoOne of the pathological consequences of diabetes due to hype...
AbstractGlycosylation is a major pathway for posttranslational modification of tissue protein and be...
Aims/hypothesis: Previous studies have implicated the glycoxidative modification of low-density lipo...
Patients with diabetes mellitus suffer from an increased incidence of complications including cardio...
Glycation of LDL occurs chiefly due to the nonenzymatic reaction of glucose and its metabolites with...
Introduction: Cardiovascular complications are the leading cause of morbidity and morality in patien...
People with diabetes mellitus have an increased incidence of atherosclerosis, possibly due to the hy...
This thesis discusses the role of transition metal catalysed oxidative reactions in the development ...
Objective: The importance of measuring the blood level of modified low-density lipoprotein (LDL) mol...
Summary: The significance of the two most common hallmarks of the diabetic state, hyperglycaemia and...
Low-density lipoprotein (LDL) in patients with diabetes is subject to modification by both oxidation...
The nonenzymatic protein glycation and the subsequent formation of advanced glycation end products i...
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: ple...
Increased oxidative stress is associated with type-2 diabetes and related cardiovascular diseases bu...
People with diabetes experience chronic hyperglycemia and are at a high risk of developing atheroscl...
grantor: University of TorontoOne of the pathological consequences of diabetes due to hype...
AbstractGlycosylation is a major pathway for posttranslational modification of tissue protein and be...
Aims/hypothesis: Previous studies have implicated the glycoxidative modification of low-density lipo...
Patients with diabetes mellitus suffer from an increased incidence of complications including cardio...
Glycation of LDL occurs chiefly due to the nonenzymatic reaction of glucose and its metabolites with...
Introduction: Cardiovascular complications are the leading cause of morbidity and morality in patien...
People with diabetes mellitus have an increased incidence of atherosclerosis, possibly due to the hy...
This thesis discusses the role of transition metal catalysed oxidative reactions in the development ...
Objective: The importance of measuring the blood level of modified low-density lipoprotein (LDL) mol...
Summary: The significance of the two most common hallmarks of the diabetic state, hyperglycaemia and...
Low-density lipoprotein (LDL) in patients with diabetes is subject to modification by both oxidation...
The nonenzymatic protein glycation and the subsequent formation of advanced glycation end products i...
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: ple...
Increased oxidative stress is associated with type-2 diabetes and related cardiovascular diseases bu...
People with diabetes experience chronic hyperglycemia and are at a high risk of developing atheroscl...