Neuropharmacological Effects of Aqueous Leaf Extract of Bryophyllum Pinnatum   in Mice

Effects of aqueous leaf extracts of Bryophyllum Pinnatum (AEBP) on some neuropharmacological activities were studied in mice. The extract in dosages (50,100 and 200 mg/kg) was found to produce a profound decrease in exploratory activity in a dose-dependent manner. It also showed a marked sedative effect as evidenced by a significant reduction in gross behaviour and potentiation of pentobarbitone-induced sleeping time. It delayed onset in strychnine-and picrotoxin-induced convulsion (seizures) respectively with the protective effect being significantly higher in picrotoxin- than strychnine-induced convulsion. It also decreases the rate of picrotoxin-induced mortality in mice with LD50 of 641mg/kg. The totality of these effects showed that the extract possesses depressant action on the central nervous syste