Short communication - EFFECT OF CRUDE GARLIC EXTRACT ON NICOTINE INDUCED HYPERGLYCAEMIA AND HYPERLIPIDEMIA IN RATS

The effect of curde garlic extract on nicotine induced hyperglycaemia and hyperlipidaemia has been studied in albino rats. Four groups of 6 rats each were used. A control group received saline, a second group received 1mg/kg nicotine i.p., the third group received 305 per kg body weight o acqueous garlic extract orally and the fourth group, nicotine + garlic (i.p). These were sacrified 24 hours after last treatment. Serum cholesterol, glucose and triglycerides were assayed by standrd procedures. Garlic treated rats had lower serum cholesterol, triglyceride and glucose levels. The Nicotine + garlic combination also decreased the levels o these parameters but less than the garlic group. Nicotine group had higher levels of the parameters but less than the garlic group. Nicotine group had higher levels of the parameters. Effects of garlic alone and garlic + nicotine was significant (P