The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice

Description: Quantitative bone marrow transplantation was used to obtain an estimate of the radiation sensitivity of normal mouse bone marrow progenitor cells. Reproduced from Radiation Research 1960(Jul); 13(1): 115-125 by copyright permission of the Radiation Research Society (www.radres.org).SUMMARY: 1. A technique for measuring the number of viable cells in a suspension of bone marrow by quantitative transplantation into supralethally irradiated mice has been described. 2. The technique was used to measure the radiation sensitivity of normal mouse bone marrow cells and yielded a result of 105 ± 24 rads as the D37 for marrow cells.The Defence Research Board of Canada and the National Cancer Institute of Canada