Investigation of acute toxicological effects of diesels fuel in rats (Rattus rattus) using histopathological methods

Acute toxicological effects of diesel fuel in rats were investigated. The LD50 value was determined as 70.6gIkg using rats of 0.2kg body weight. Histopathological examination of rat tissues after exposure of rat groups to 0.9% saline (controlgroup), LD50 and LD100 of diesel fuel for 24 hour revealed black deposits and inplamination respectively in the pulmonary interstitium, and necrosis of the kidney and liver of rats administered with diesel fuel. From the international classification of the toxicity of chemicals based on their LD50 values, diesel fuel seemed to be relatively harmless, however, there is the need for caution in the use of the petroleum product as direct effect of it on tissues indicated toxicity. @ JASE