Add to ORKGPerillyl alcohol and d-limonene are naturally occurring plant compounds that exhibited anti-carcinogenic activities in mammary tumor models. The effects of these monoterpenes at the initiation stage of aflatoxin B1-induced hepatocarcinogenesis were investigated. Male F344 rats were fed Control or treatment diets throughout the study and exposed to aflatoxin for 5 days. Three days after the last aflatoxin dose, blood and liver samples were obtained. Analysis of liver samples showed that both limonene and perillyl alcohol significantly inhibited (p<0.05) aflatoxin-DNA adducts formation in hepatocytes. The monoterpenes may have potential for use as chemopreventive agent against aflatoxin-induced liver cancer
Chemopreventive agents are compounds that inhibit carcino-genesis when administered prior or subsequ...
Essential oils from common spices such as nutmeg, ginger, cardamom, celery, xanthoxylum, black peppe...
The cancer-initiating potential of the fumonisin B (FB) mycotoxins produced by Fusarium moniliforme ...
In experimental animals and humans, aflatoxin B1 (AFB 1) is a potent hepatic toxin and carcinogen. T...
Synthetic triterpenoid analogues of oleanolic acid are potent inducers of the phase 2 response as we...
Structurally diverse compounds can confer resistance to aflatoxin B1 (AFB1) hepatocarcinogenesis in ...
Dietary co-exposure to aflatoxin B1 (AFB1) and fumonisin B1 (FB1) and their interaction on hepatocel...
^To whom requests for reprints should be sent We have previously demonstrated the cancer chemopreven...
Populations consuming aflatoxin (AF) and fumonisin (FN)-contaminated foods may be at increased risk ...
Using an 8 week Solt-Farber protocol with selection pressure (2-acetylaminofluorene/partial hepatect...
The principal objective of this study is to provide more extensive description of the chemopreventiv...
Aflatoxin B1 (AFB1) is a fungal toxin that has been associated with primary hepatocellular carcinoma...
In the context of the steadily increasing prevalence of malignant disorders all over the world, iden...
Aflatoxin B1 (AFB1), a fungal toxin produced by Aspergillus flavus, is known to be a possible hepato...
AbstractAflaxton B1 rapidly inhibits RNA synthesis in rat liver cells, slices or liver in vivo. Esta...
Chemopreventive agents are compounds that inhibit carcino-genesis when administered prior or subsequ...
Essential oils from common spices such as nutmeg, ginger, cardamom, celery, xanthoxylum, black peppe...
The cancer-initiating potential of the fumonisin B (FB) mycotoxins produced by Fusarium moniliforme ...
In experimental animals and humans, aflatoxin B1 (AFB 1) is a potent hepatic toxin and carcinogen. T...
Synthetic triterpenoid analogues of oleanolic acid are potent inducers of the phase 2 response as we...
Structurally diverse compounds can confer resistance to aflatoxin B1 (AFB1) hepatocarcinogenesis in ...
Dietary co-exposure to aflatoxin B1 (AFB1) and fumonisin B1 (FB1) and their interaction on hepatocel...
^To whom requests for reprints should be sent We have previously demonstrated the cancer chemopreven...
Populations consuming aflatoxin (AF) and fumonisin (FN)-contaminated foods may be at increased risk ...
Using an 8 week Solt-Farber protocol with selection pressure (2-acetylaminofluorene/partial hepatect...
The principal objective of this study is to provide more extensive description of the chemopreventiv...
Aflatoxin B1 (AFB1) is a fungal toxin that has been associated with primary hepatocellular carcinoma...
In the context of the steadily increasing prevalence of malignant disorders all over the world, iden...
Aflatoxin B1 (AFB1), a fungal toxin produced by Aspergillus flavus, is known to be a possible hepato...
AbstractAflaxton B1 rapidly inhibits RNA synthesis in rat liver cells, slices or liver in vivo. Esta...
Chemopreventive agents are compounds that inhibit carcino-genesis when administered prior or subsequ...
Essential oils from common spices such as nutmeg, ginger, cardamom, celery, xanthoxylum, black peppe...
The cancer-initiating potential of the fumonisin B (FB) mycotoxins produced by Fusarium moniliforme ...