Effect of Distal Esophageal Irritation on the Changes of Cystometry Parameters to Esophagus and Colon Distentions in Rats

The coexistence of different visceral pathologies on patients suffering from irritable bowel syndrome, interstitial cystitis, and other pathologies, necessitates the study of theses pathologies under complicated conditions. In the present study, cystometry recordings were used to investigate the effect of distal esophageal chemical irritation (DEI) on the urinary bladder interaction with distal colon distention (DCD), distal esophageal distention (DED), and electrical stimulation of abdominal branches of vagus nerve (abd-vagus). DEI significantly decreased the intercontraction time (ICT) via decreasing the voiding time (VT). DEI, also, significantly decreased the pressure amplitude (P-amplitude) by decreasing the maximum pressure (MP). Following DEI, DED was able to significantly decrease the ICT by decreasing the storage time (ST). Whereas, 3 ml DCD significantly increased the ICT by increasing the ST. On the other hand, following DEI, abd-vagus didnâ t have any significant effect on ICT. However, abd-vagus significantly increased the P-amplitude by increasing the MP. The results of this study demonstrate that urinary bladder function and interaction of bladder with other viscera can be affected by chemical irritation of distal esophagus.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author