O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serious human pathologies, such as diabetes and cancer. However, the limited availability of potent and selective inhibitors hinders the validation of this potential therapeutic target. To explore new chemotypes that target the active site of OGT, we performed virtual screening of a large library of commercially available compounds with drug-like properties. We purchased samples of the most promising virtual hits and used enzyme assays to identify authentic leads. Structure-activity relationships of th...
Resumen del trabajo presentado al 12th Spanish-Italian Symposium on Organic Chemistry (SISOC), celeb...
AbstractO-GlcNAcylation is an essential posttranslational modification in metazoa. Modulation of O-G...
O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc posttransl...
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl...
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β- N-acety...
Abstract O-GlcNAc transferase (OGT) plays an important role in regulating numerous cellular processe...
O-GlcNAcylation is an important posttranslational and metabolic process in cells that must be carefu...
O-GlcNAcylation is an important post-translational and metabolic process in cells that must be caref...
TheO-linked beta-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is a master regulator of installin...
Attachment of GlcNAc via a β-O-linkage to serine or threonine residues of various nucleocytoplasmic ...
A series of glycomimetics of UDP-GlcNAc, in which the β-phosphate has been replaced by either an alk...
<i>O</i>-GlcNAc transferase (OGT) is an essential mammalian enzyme that regulates numerous cellular ...
Intracellular protein O-glycosylation is an important post-translational modification in mammalian c...
O-GlcNAcylation is an essential posttranslational modification in metazoa. Modulation of O-GlcNAc le...
The O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification (O-GlcNAcylation) is the...
Resumen del trabajo presentado al 12th Spanish-Italian Symposium on Organic Chemistry (SISOC), celeb...
AbstractO-GlcNAcylation is an essential posttranslational modification in metazoa. Modulation of O-G...
O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc posttransl...
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl...
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β- N-acety...
Abstract O-GlcNAc transferase (OGT) plays an important role in regulating numerous cellular processe...
O-GlcNAcylation is an important posttranslational and metabolic process in cells that must be carefu...
O-GlcNAcylation is an important post-translational and metabolic process in cells that must be caref...
TheO-linked beta-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is a master regulator of installin...
Attachment of GlcNAc via a β-O-linkage to serine or threonine residues of various nucleocytoplasmic ...
A series of glycomimetics of UDP-GlcNAc, in which the β-phosphate has been replaced by either an alk...
<i>O</i>-GlcNAc transferase (OGT) is an essential mammalian enzyme that regulates numerous cellular ...
Intracellular protein O-glycosylation is an important post-translational modification in mammalian c...
O-GlcNAcylation is an essential posttranslational modification in metazoa. Modulation of O-GlcNAc le...
The O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification (O-GlcNAcylation) is the...
Resumen del trabajo presentado al 12th Spanish-Italian Symposium on Organic Chemistry (SISOC), celeb...
AbstractO-GlcNAcylation is an essential posttranslational modification in metazoa. Modulation of O-G...
O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc posttransl...