Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia caused by mutations in endoglin (ENG; HHT1) or activin receptor-like kinase (ALK1; HHT2) genes, coding for transforming growth factor- (TGF-) superfamily receptors. We demonstrated previously that endoglin and ALK1 interact with endothelial NO synthase (eNOS) and affect its activation. Endothelial cells deficient in endoglin or ALK1 proteins show eNOS uncoupling, reduced NO, and increased reactive oxygen species (ROS) production. In this study, we measured NO and H2O2 levels in several organs of adult Eng and Alk1 heterozygous mice, to ascertain whether decreased NO and increased ROS production is a generalized manifestation of HHT. A significant reduction in NO and increas...
AbstractGrowth hormone deficiency is linked to cardiovascular disease and particularly increased per...
Background and purpose: The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelia...
<div><p>Mutations affecting transforming growth factor-beta (TGF-β) superfamily receptors, activin r...
The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telang...
grantor: University of TorontoEndoglin, (CD105), an integral membrane glycoprotein, is a m...
Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic vascular disease in which arteriovenous mal...
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder characterized...
Rationale: Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease caused by mutations in E...
Rationale: Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease caused by mutations in E...
AbstractSeveral characteristic morphological and functional differences distinguish arteries from ve...
Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder in humans that is cha...
Endothelial dysfunction in vascular disease states is associated with reduced NO bioactivity and inc...
BACKGROUND: Endothelial dysfunction in widely diffuse disorders, such as atherosclerosis, hypertensi...
11 p.-6 fig.Endoglin, a transforming growth factor β (TGF-β) receptor type III, is co-expressed with...
Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) func...
AbstractGrowth hormone deficiency is linked to cardiovascular disease and particularly increased per...
Background and purpose: The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelia...
<div><p>Mutations affecting transforming growth factor-beta (TGF-β) superfamily receptors, activin r...
The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telang...
grantor: University of TorontoEndoglin, (CD105), an integral membrane glycoprotein, is a m...
Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic vascular disease in which arteriovenous mal...
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder characterized...
Rationale: Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease caused by mutations in E...
Rationale: Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease caused by mutations in E...
AbstractSeveral characteristic morphological and functional differences distinguish arteries from ve...
Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder in humans that is cha...
Endothelial dysfunction in vascular disease states is associated with reduced NO bioactivity and inc...
BACKGROUND: Endothelial dysfunction in widely diffuse disorders, such as atherosclerosis, hypertensi...
11 p.-6 fig.Endoglin, a transforming growth factor β (TGF-β) receptor type III, is co-expressed with...
Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) func...
AbstractGrowth hormone deficiency is linked to cardiovascular disease and particularly increased per...
Background and purpose: The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelia...
<div><p>Mutations affecting transforming growth factor-beta (TGF-β) superfamily receptors, activin r...