Novel N-chloramine precursors for antimicrobial application: synthesis and facile covalent immobilization on polyurethane surface based on Perfluorophenyl azide (PFPA) chemistry

To control the pathogen cross contaminations on medical material surface, there is a pressing need to develop antimicrobial materials with highly efficacious surface biocidal activity. In this work, N-Chloramine precursors containing quaternary ammonium unit and perfluorophenyl azide unit were synthesized and covalently immobilized on inert polyurethane (PU) film upon UV light irradiation. The surface modification was confirmed by contact angle, Fourier transform infrared (ATR FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) analyses. After bleaching treatment, satisfactory biocidal activity was achieved for the surface modified PU films. It was found that the introduced surface QA center contributed an even faster surface contact killing behavior, and that precursors with longer structural linker caused higher surface chlorine content and higher antimicrobial efficacy. This approach provides a novel and facile method which enables the covalent immobilization of N-chloramine precursors on inert polymeric surface to produce durable antimicrobial materials. Keyword: N-chloramine antibacterial agents; Organic synthesis; Perfluorophenyl azide chemistry; Polyurethane surface modificationThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author