An Convenient Approach to 2,4-Disubstituted Quinazoline 3-Oxides Using active MnO2 as Oxidant

Using cheap, readily available and economic active MnO2 as an oxidant, a series of 2,4-disubstituted quinazoline-3-oxides were synthesized in good to excellent yields by oxidation of the corresponding 1,2-dihydroquinazoline-3-oxides under mild conditions. The novel approach is simple and convenient, which provide a series of 2,4-Disubstituted quinazoline-3-oxides.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author