Resting Metabolic Rate in Adults with Facioscapulohumeral Muscular Dystrophy (FSHD)

Determine whether resting metabolic rate (RMR) is altered in adults with facioscapulohumeral muscular dystrophy (FSHD). Eleven people with FSHD (5112yrs, 2 females) and eleven controls (4814yrs, 2 females) completed one visit, including 30-minutes of indirect calorimetry and dual-energy x-ray absorptiometry (DXA) scanning. RMR was calculated from resting oxygen consumption/carbon dioxide production; regional/whole-body fat mass and lean mass were collected from the DXA scan. Absolute RMR was 15% lower in FSHD (p=0.04); when normalized to regional/local lean mass, no differences in RMR were observed (p>0.05). Absolute RMR was correlated with total lean mass for all participants combined (pThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author