Independent assortment of GC gene polymorphism (rs2282679) and 25-hydroxyvitamin D levels in Coronary Artery Disease

BACKGROUND: Coronary artery disease (CAD) remains a major public health burden. Emerging research has suggested an association between vitamin D insufficiency and CAD. Vitamin D binding protein (VDBP) is the primary vitamin D carrier and many of its genetic polymorphisms are able to induce the expression of proteins with different affinities for the vitamin, which in turn, might affect its serum levels and CAD incidence. SUBJECTS/METHODS: 112 male patients, aged between 35 and 50, with verified CAD and 109 age- and sex-matched controls were recruited. Genotyping was performed by the TaqMan allelic discrimination assay and plasma 25(OH)D levels were assessed by HPLC-UV. Serum parathyroid hormone (PTH) and VDBP levels were measured using ELISA. RESULTS: s-25(OH)D levels in CAD patients were significantly lower than the controls. Whereas, s-PTH levels were significantly higher in the CAD patients than in controls. There was no significant difference in the distribution of GC genotypes among both groups. s-25(OH)D showed a weak inverse correlation with s-PTH levels. CONCLUSIONS: Serum levels of vitamin D and PTH are highly correlated to CAD incidence. However, s-VDBP level is neither associated with disease outcome nor with vitamin D status. GC gene variant has no effect on 25(OH)D levels.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author