Oxidative stress is involved in the development of various cancers. In the present study the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated. Both substances were administered in a preventive/curative manner (12 days before and 16 weeks after the carcinogen application). Carcinogen administration induced oxidative stress: the level of thiobarbituric acid reactive products (TBARS) as a marker of reactive oxygen species (ROS) generation in liver increased as well as the level of oxidatively modified protein content (OMP, aldehyde and ketone derivates)....
The aim of this study was to evaluate the effect of melatonin (MEL) on N-methyl-N-nitrosourea (NMU)-...
Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endo...
AbstractEffect of Metformin in chemically induced hepatocarcinogenesis was assessed in Wistar rats. ...
Oxidative stress is involved in the development of various cancers. In the present study the effect ...
Purpose: Melatonin (N-acetyl-5-methoxy-tryptamine) is synthesized mainly by the pineal gland and its...
Antioxidant properties have been attributed to melatonin; it seemed therefore worthwhile to determin...
This study investigated the possible protective effects of melatonin as an antioxidant against strep...
An enormous amount of data has been published in recent years demonstrating melatonin's defensive ro...
Background: Because radiotherapy is one of the causes of primary or secondary ovarian failure, prote...
Background/Aims: The protective effect of melatonin against the damage inflicted by reactive oxygen ...
We investigated the effects of acute high doses of acetylsalicylic acid (ASA) on liver tissue and th...
AbstractOxidative stress produced by free radicals has been implicated in the pathogenesis of acute ...
Regarding the mechanisms of methotrexate (MTX) hepatotoxicity and nephrotoxicity, several hypotheses...
Objective: Ionizing radiation interacts with biological systems to induce excessive fluxes of free r...
WOS: 000400553200039Formaldehyde (FA) is an organic chemical which is widely used all over the world...
The aim of this study was to evaluate the effect of melatonin (MEL) on N-methyl-N-nitrosourea (NMU)-...
Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endo...
AbstractEffect of Metformin in chemically induced hepatocarcinogenesis was assessed in Wistar rats. ...
Oxidative stress is involved in the development of various cancers. In the present study the effect ...
Purpose: Melatonin (N-acetyl-5-methoxy-tryptamine) is synthesized mainly by the pineal gland and its...
Antioxidant properties have been attributed to melatonin; it seemed therefore worthwhile to determin...
This study investigated the possible protective effects of melatonin as an antioxidant against strep...
An enormous amount of data has been published in recent years demonstrating melatonin's defensive ro...
Background: Because radiotherapy is one of the causes of primary or secondary ovarian failure, prote...
Background/Aims: The protective effect of melatonin against the damage inflicted by reactive oxygen ...
We investigated the effects of acute high doses of acetylsalicylic acid (ASA) on liver tissue and th...
AbstractOxidative stress produced by free radicals has been implicated in the pathogenesis of acute ...
Regarding the mechanisms of methotrexate (MTX) hepatotoxicity and nephrotoxicity, several hypotheses...
Objective: Ionizing radiation interacts with biological systems to induce excessive fluxes of free r...
WOS: 000400553200039Formaldehyde (FA) is an organic chemical which is widely used all over the world...
The aim of this study was to evaluate the effect of melatonin (MEL) on N-methyl-N-nitrosourea (NMU)-...
Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endo...
AbstractEffect of Metformin in chemically induced hepatocarcinogenesis was assessed in Wistar rats. ...