Add to ORKGCross-reactivity and direct killing of target cells remain underexplored for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific CD8+ T cells. Isolation of T cell receptors (TCRs) and overexpression in allogeneic cells allows for extensive T cell reactivity profiling. We identify SARS-CoV-2 RNA-dependent RNA polymerase (RdRp/NSP12) as highly conserved, likely due to its critical role in the virus life cycle. We perform single-cell TCRαβ sequencing in human leukocyte antigen (HLA)-A∗02:01-restricted, RdRp-specific T cells from SARS-CoV-2-unexposed individuals. Human T cells expressing these TCRαβ constructs kill target cell lines engineered to express full-length RdRp. Three TCR constructs recognize homologous epitopes from...
Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (S...
A better understanding of the role of T cells in the immune response to Severe Acute Respiratory Syn...
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is n...
Cross-reactivity and direct killing of target cells remain underexplored for severe acute respirator...
Cross-reactivity and direct killing of target cells remain underexplored for severe acute respirator...
CD8+ T cells play an important role in vaccination and immunity against severe acute respiratory syn...
T cells are required for effective vaccination and resolution of many infections. CD4 and CD8 T cell...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is n...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to CD8+ T cell...
The adaptive immune system provides protection against disease and maintains memory of past exposure...
The data currently available on how the immune system recognises the SARS-CoV-2 virus is growing rap...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
Coronavirus disease 2019 (COVID-19) is a global infectious disease caused by the SARS-CoV-2 coronavi...
Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (S...
A better understanding of the role of T cells in the immune response to Severe Acute Respiratory Syn...
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is n...
Cross-reactivity and direct killing of target cells remain underexplored for severe acute respirator...
Cross-reactivity and direct killing of target cells remain underexplored for severe acute respirator...
CD8+ T cells play an important role in vaccination and immunity against severe acute respiratory syn...
T cells are required for effective vaccination and resolution of many infections. CD4 and CD8 T cell...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is n...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to CD8+ T cell...
The adaptive immune system provides protection against disease and maintains memory of past exposure...
The data currently available on how the immune system recognises the SARS-CoV-2 virus is growing rap...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
Coronavirus disease 2019 (COVID-19) is a global infectious disease caused by the SARS-CoV-2 coronavi...
Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (S...
A better understanding of the role of T cells in the immune response to Severe Acute Respiratory Syn...
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is n...