Add to ORKGLong-term hyperglycemia in diabetic patients leads to human serum albumin (HSA) glycation, which may impair HSA function as a transport protein and affect the therapeutic efficacy of anticoagulants in diabetic patients. In this study, a novel mass spectrometry (MS) approach was developed to reveal the differences in the profiles of HSA glycation sites between diabetic and healthy subjects. K199 was the glycation site most significantly changed in diabetic patients, contributing to different interactions of glycated HSA (gHSA) and normal HSA with two types of anticoagulant drugs, heparin and warfarin
Diabetes leads to elevated levels of glucose in blood which, in turn, can lead to the non-enzymatic ...
Introduction Recent studies revealedN-glycosylation signatures of type 2 diabetes, inflammation and ...
Human serum albumin (HSA) is the most abundant protein in serum and is responsible for the transport...
Long-term hyperglycemia in diabetic patients leads to human serum albumin (HSA) glycation, which may...
The modification of proteins by reducing sugars is a process that occurs naturally in the body. This...
Diabetes is a metabolic disease that can lead to the non-enzymatic glycation of serum proteins such ...
Diabetes is a metabolic disease that can lead to the non-enzymatic glycation of serum proteins such ...
Background—The glycation of human serum albumin (HSA) during diabetes can affect the ability of this...
Diabetes is a health condition associated with the elevated levels of glucose in the bloodstream and...
The presence of elevated glucose concentrations in diabetes is a metabolic change that leads to an i...
Background—Many of the complications encountered during diabetes can be linked to the nonenzymatic g...
The modification of proteins by reducing sugars is a process that occurs naturally in the body. This...
Copyright © 2013 Annunziata Lapolla et al. This is an open access article distributed under the Crea...
Albumin, the major circulating protein in blood plasma, can be subjected to an increased level of gl...
Background—One of the long term complications of diabetes is the non-enzymatic addition of glucose t...
Diabetes leads to elevated levels of glucose in blood which, in turn, can lead to the non-enzymatic ...
Introduction Recent studies revealedN-glycosylation signatures of type 2 diabetes, inflammation and ...
Human serum albumin (HSA) is the most abundant protein in serum and is responsible for the transport...
Long-term hyperglycemia in diabetic patients leads to human serum albumin (HSA) glycation, which may...
The modification of proteins by reducing sugars is a process that occurs naturally in the body. This...
Diabetes is a metabolic disease that can lead to the non-enzymatic glycation of serum proteins such ...
Diabetes is a metabolic disease that can lead to the non-enzymatic glycation of serum proteins such ...
Background—The glycation of human serum albumin (HSA) during diabetes can affect the ability of this...
Diabetes is a health condition associated with the elevated levels of glucose in the bloodstream and...
The presence of elevated glucose concentrations in diabetes is a metabolic change that leads to an i...
Background—Many of the complications encountered during diabetes can be linked to the nonenzymatic g...
The modification of proteins by reducing sugars is a process that occurs naturally in the body. This...
Copyright © 2013 Annunziata Lapolla et al. This is an open access article distributed under the Crea...
Albumin, the major circulating protein in blood plasma, can be subjected to an increased level of gl...
Background—One of the long term complications of diabetes is the non-enzymatic addition of glucose t...
Diabetes leads to elevated levels of glucose in blood which, in turn, can lead to the non-enzymatic ...
Introduction Recent studies revealedN-glycosylation signatures of type 2 diabetes, inflammation and ...
Human serum albumin (HSA) is the most abundant protein in serum and is responsible for the transport...