This research project aims to develop accurate biological clocks to measure age and aging rates in organisms at various levels, from whole systems to individual cells. To ensure the applicability of the results to the human population, a diverse mouse population is being used as a model. Various statistical analysis techniques were employed to identify potential genetic markers for constructing biological clocks to measure internal aging noninvasively and accurately. This summer\u27s focus was on predicting aging with early time points and identifying strains that serve as the best indicators for variation in aging
International audienceThe concept of healthy ageing today is linked to the efforts of maintaining ph...
Complete dataset of Methylation and Telomere studies searched, retrieved, analysed, extracted and co...
Abstract Epigenetic clocks provide powerful tools to evaluate nutritional, hormonal, and genetic eff...
The aging process results in multiple traceable footprints, which can be quantified and used to esti...
The identification of genes and interventions that slow or reverse aging is hampered by the lack of ...
International audienceAging is the major risk factor for the development of chronic diseases. After ...
Biomarkers of agingwould be highly desirable, but so far, a definitive panel of biomarkers to predic...
Aging in mammals is a complex process encompassing a plethora of phenotypic changes. This thesis des...
The use of genomic technologies in biogerontology has the potential to greatly enhance our understan...
Understanding the source of genetic variation in aging and using this variation to define the molecu...
The relationship between chronological age (lifespan) and biological age (healthspan) varies amongst...
Estimators of biological age (BA) – defined as the hypothetical underlying age of an organism – have...
The diversity of cell types is a challenge for quantifying aging and its reversal. Here we develop '...
International audienceThe concept of healthy ageing today is linked to the efforts of maintaining ph...
Complete dataset of Methylation and Telomere studies searched, retrieved, analysed, extracted and co...
Abstract Epigenetic clocks provide powerful tools to evaluate nutritional, hormonal, and genetic eff...
The aging process results in multiple traceable footprints, which can be quantified and used to esti...
The identification of genes and interventions that slow or reverse aging is hampered by the lack of ...
International audienceAging is the major risk factor for the development of chronic diseases. After ...
Biomarkers of agingwould be highly desirable, but so far, a definitive panel of biomarkers to predic...
Aging in mammals is a complex process encompassing a plethora of phenotypic changes. This thesis des...
The use of genomic technologies in biogerontology has the potential to greatly enhance our understan...
Understanding the source of genetic variation in aging and using this variation to define the molecu...
The relationship between chronological age (lifespan) and biological age (healthspan) varies amongst...
Estimators of biological age (BA) – defined as the hypothetical underlying age of an organism – have...
The diversity of cell types is a challenge for quantifying aging and its reversal. Here we develop '...
International audienceThe concept of healthy ageing today is linked to the efforts of maintaining ph...
Complete dataset of Methylation and Telomere studies searched, retrieved, analysed, extracted and co...
Abstract Epigenetic clocks provide powerful tools to evaluate nutritional, hormonal, and genetic eff...