Mutations in mitochondrial DNA (mtDNA) contribute to a variety of serious multi-organ human diseases, which are strictly inherited from the maternal germline. However, there is currently no curative treatment. Attention has been focused on preventing the transmission of mitochondrial diseases through mitochondrial replacement (MR) therapy, but levels of mutant mtDNA can often unexpectedly undergo significant changes known as mitochondrial genetic drift. Here, we proposed a novel strategy to perform spindle-chromosomal complex transfer (SCCT) with maximal residue removal (MRR) in metaphase II (MII) oocytes, thus hopefully eliminated the transmission of mtDNA diseases. With the MRR procedure, we initially investigated the proportions of mtDNA...
Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad range o...
Erratum in • Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mito...
One in 400 people has a maternally inherited mutation in mtDNA potentially causing incurable disease...
Mutations in mitochondrial DNA (mtDNA) contribute to a variety of serious multi-organ human diseases...
Mutations in mitochondrial DNA (mtDNA) contribute to a variety of serious multi-organ human diseases...
Mitochondria are found in all eukaryotic cells and contain their own genome (mtDNA). Unlike the nucl...
Prevention of mitochondrial DNA (mtDNA) diseases may currently be possible using germline nuclear tr...
The definitive version is available at www.blackwell-synergy.comThe mammalian mitochondrial genome e...
The mitochondria contained in eukaryotic cells have their own DNA, and heritable mutations in mitoch...
(A) MtDNA proportions of SCC karyoplasts in corresponding enucleated human oocytes (mtDNA copy numbe...
Recent reports of strong selection of mitochondrial DNA (mtDNA) during transmission in animal models...
Abstract Background Recent technological development allows nearly complete replacement of the cytop...
Mitochondria are the energy producing organelles in a cell, possessing their own genetic content, th...
Maternally inherited mitochondrial DNA (mtDNA) mutations are a common cause of genetic disease. Howe...
SummaryInherited mtDNA diseases transmit maternally and cause severe phenotypes. Currently, there is...
Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad range o...
Erratum in • Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mito...
One in 400 people has a maternally inherited mutation in mtDNA potentially causing incurable disease...
Mutations in mitochondrial DNA (mtDNA) contribute to a variety of serious multi-organ human diseases...
Mutations in mitochondrial DNA (mtDNA) contribute to a variety of serious multi-organ human diseases...
Mitochondria are found in all eukaryotic cells and contain their own genome (mtDNA). Unlike the nucl...
Prevention of mitochondrial DNA (mtDNA) diseases may currently be possible using germline nuclear tr...
The definitive version is available at www.blackwell-synergy.comThe mammalian mitochondrial genome e...
The mitochondria contained in eukaryotic cells have their own DNA, and heritable mutations in mitoch...
(A) MtDNA proportions of SCC karyoplasts in corresponding enucleated human oocytes (mtDNA copy numbe...
Recent reports of strong selection of mitochondrial DNA (mtDNA) during transmission in animal models...
Abstract Background Recent technological development allows nearly complete replacement of the cytop...
Mitochondria are the energy producing organelles in a cell, possessing their own genetic content, th...
Maternally inherited mitochondrial DNA (mtDNA) mutations are a common cause of genetic disease. Howe...
SummaryInherited mtDNA diseases transmit maternally and cause severe phenotypes. Currently, there is...
Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad range o...
Erratum in • Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mito...
One in 400 people has a maternally inherited mutation in mtDNA potentially causing incurable disease...