Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus
- Buyu Kou (3907639)
- Zhisen Zhang (1317528)
- Xingchun Han (5860709)
- Zheng Zhou (152309)
- Zhiheng Xu (1751443)
- Xue Zhou (68629)
- Fang Shen (495200)
- Yuan Zhou (179597)
- Xiaojun Tian (3907636)
- Guang Yang (154978)
- John A. T. Young (12599284)
- Hongxia Qiu (2861948)
- Giorgio Ottaviani (1503034)
- Alexander Mayweg (17108486)
- Wei Zhu (23646)
- Hong C. Shen (1622356)
- Haixia Liu (764025)
- Taishan Hu (352102)
Publication date
October 2023
DOIAbstract
Hepatitis B Virus (HBV) core protein allosteric modulators (CpAMs) are an attractive class of potential anti-HBV therapeutic agents. Here we describe the efforts toward the discovery of a series of 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine (THPP) compounds as HBV CpAMs that effectively inhibit a broad range of nucleos(t)ide-resistant HBV variants. The lead compound 45 demonstrated inhibition of HBV DNA viral load in a HBV AAV mouse model by oral administration
Add to ORKG