TYG-BMI AS A SURROGATE MARKER IN HYPERTENSIVE PATIENTS - AN OBSERVATIONAL STUDY IN TERTIARY CARE HOSPITAL

<p><strong>Background:</strong> Previous epidemiological studies have shown that the triglyceride-glucose index (Ty-G) was well- known predictor for the development of diabetes mellitus. A study proposed that traditional lipid ratios, particularly the TGHDL- C ratio based on the proportion between pro atherogenic and anti-atherogenic fractions are more effective than single lipids measure in identifying IR. Ty-G index predicted the subsequent occurrence of HTN in a positive and dose-dependent manner. Therefore, early detection of the Ty-G index may be beneficial for early interventions to prevent HTN among the Chinese population</p> <p><strong>Methodology</strong>: The present study was an observational study and the results of total 128 hypertensive patients and healthy volunteers aged between 35 to 60 years was collected from a Tertiary care hospital. <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/body-mass-index">Body mass index</a> (BMI), Waist Circumference (WC), blood pressure, fasting blood glucose and Triglyceride levels were measured. Receiver Operating Characteristic (ROC) Curve was used to check association between the study groups.</p> <p><strong>Results</strong>: ROC curve based on sensitivity and specificity with reference to TyG-BMI as dependent variable among the groups. Area under curve for Waist/Hip ratio(W/H) was 0.543, HbA1c was 0.766, albumin/creatinine was 0.512, aspartate aminotransferase/alanine aminotransferase was 0.528, triacylglycerol/high density lipoprotein was 0.681 with cut-off value of W/H is 0.81, HbA1c is 5.05, albumin/creatinine is 2.56, AST/ALT is 0.41, TAG/HDL is 0.71 respectively. TyG-WC as dependent variable in normotensive and hypertensive subjects, area under curve for     W/H was 0.626, HbA1c was 0.671, albumin/creatinine was 0.527, AST/ALT was 0.528, TAG/HDL was 0.681 with cut-off value of W/H ratio is 0.80, HbA1c is 5.05, albumin/creatinine is 2.56, AST/ALT is 0.55, TAG/HDL is 1.64 respectively.</p> <p><strong>Conclusion:</strong> Our observational study suggests that higher Ty-G index was associated with higher probabilities of hypertension in general adult population. Large-scale prospective cohort studies are looked-for to elucidate the latent pathophysiological mechanisms underlying the association among Ty-G index and hypertensive subjects.</p> <p> </p&gt