Subacute toxiciteit van propylgallaat

The 4 week oral toxicity of propyl gallate in rats, exposed to 0, 1000, 5000 and 25000 mg/kg feed, was investigated. Parameters studied comprised growth, food and water intake, biochemistry, hematology, organ weights and histopathology. In the highest dose group both females and males gained less weight than those in the control group. Hemoglobin concentration, packed cell volume, red blood cell concentration, mean corpuscular volume and mean corpuscular hemoglobin were lowered in the highest dose group (males and females). In accordance with the anemia, an increased extramedullary hematopoiesis and slightly descreased hemosiderosis were noted in the spleen. In kidneys hyperplastic tubuli in the outer medulla were detected. In liver of the 5000 and 25000 mg/kg fed groups increases in activity of aminopyrin-N-demethylase and glucuronyltransferase and glutathione S-transferase and an increase in cytochrome P-450 content were detected. Based on these data a semi-chronic feeding study with a dose range of 1000-10000 mg propyl gallate/kg feed, and a detailed study into the mechanism of the hyperplastic tubular alterations in kidneys, are suggested.HI