Present situation of the drug-resistance problem in Malaria

This article is an abstract of the special paper read at the 14th annual meeting of the Japanese Society of Tropical Medicine held in Nagasaki, Japan, on November 27 and 28, 1972. The distributions of the drug-resistant malaria strains were introduced as refered to the WHO and other publications. Drugs stated in relation to this subject were chloroquine, pyrimethamine, proguanil, quinine, mepacrine, primaquine, and others. It was pointed out that the chloroquine-resistant falciparum strains have been distributing widely everywhere in the endemic areas except Africa and showing the cross-resistance to other antimalarials in common use. The effect of several sulfas to malaria was emphasized but the possible development of the resistant parasites to these sulfas was warned as the future problem to be noticed