Experimental Glomerulonephritis in Rats Produced with Soluble Antigen-Antibody Complexes after Pretreatment with Aminonucleoside

The pathogenesis of human glomerulonephritis has not been throughly recognized in spite of many extensive experimental examinations and clinical observations. With regard to experimental glomerulonephritis, MASUGI's nephritis and glomerulonephritis in serum sickness has been believed to play an important role. In serum sickness, glomerulonephritis develops during the immune phase of antigen elimination, and antigen-antibody complexes play an important role in the pathogenesis of glomerulonephritis and vascular lesions. It has been also reported that an aminonucleoside, 6-dimethylamino, 3-amino-d-ribose, increased permeability of the glomerular basement membrane for protein. In the present study pretreated rats with aminonucleoside received smaller amount of soluble antigen-antibody complexes in antigen excess which were produced in vitro between BSA anti-BSA rat serum or human γ-gl. anti-human γ-gl. rabbit serum. Glomerulonephritis developed in a short time after administration of immune complexes