Deep spatial-omics analysis of Head & Neck carcinomas provides alternative therapeutic targets and rationale for treatment failure
- Andrew Causer
- Xiao Tan
- Xuehan Lu
- Philip Moseley
- Siok M. Teoh
- Natalie Molotkov
- Margaret McGrath
- Taehyun Kim
- Peter T. Simpson
- Christopher Perry
- Ian H. Frazer
- Benedict Panizza
- Rahul Ladwa
- Quan Nguyen
- Jazmina L. Gonzalez-Cruz
DOIAbstract
Abstract Immune checkpoint inhibitor (ICI) therapy has had limited success (<30%) in treating metastatic recurrent Head and Neck Oropharyngeal Squamous Cell Carcinomas (OPSCCs). We postulate that spatial determinants in the tumor play a critical role in cancer therapy outcomes. Here, we describe the case of a male patient diagnosed with p16+ OPSCC and extensive lung metastatic disease who failed Nivolumab and Pembrolizumab/Lenvatinib therapies. Using advanced integrative spatial proteogenomic analysis on the patient’s recurrent OPSCC tumors we demonstrate that: (i) unbiased tissue clustering based on spatial transcriptomics (ST) successfully detected tumor cells and enabled the investigation of phenotypic traits such as proliferation or dru...
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