Aims: Fibroblast growth factor (FGF) signalling is dysregulated in multiple sclerosis (MS) and other neurological and psychiatric conditions, but there is little or no consensus as to how individual FGF family members contribute to disease pathogenesis. Lesion development in MS is associated with increased expression of FGF1, FGF2 and FGF9, all of which modulate remyelination in a variety of experimental settings. However, FGF9 is also selectively upregulated in major depressive disorder (MDD) prompting us to speculate it may also have a direct effect on neuronal function and survival. Methods: Transcriptional profiling of myelinating cultures treated with FGF1, FGF2 or FGF9 was performed and the effects of FGF9 on cortical neurons inv...
Objective: Hippocampal insults have been observed in multiple sclerosis (MS) patients. Fibroblast g...
Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS l...
Fragile X syndrome (FXS) is the most common single-gene inherited form of intellectual disability, w...
Aims: Fibroblast growth factor (FGF) signalling is dysregulated in multiple sclerosis (MS) and othe...
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. In around ...
Remyelination failure plays an important role in the pathophysiology of multiple sclerosis, but the ...
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervo...
Analysis of the effects of three members of the FGF family (FGF1, FGF2 and FGF9) and bone morphogeni...
Background/Aims: Huntington’s disease (HD) is a heritable neurodegenerative disorder, and there is n...
Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS l...
Fibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple scleros...
Fibroblast growth factor (FGF) signaling is involved in the pathogenesis of multiple sclerosis (MS)....
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous sy...
The role of the fibroblast growth factor (FGF) system in brain-related disorders has received consid...
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous sy...
Objective: Hippocampal insults have been observed in multiple sclerosis (MS) patients. Fibroblast g...
Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS l...
Fragile X syndrome (FXS) is the most common single-gene inherited form of intellectual disability, w...
Aims: Fibroblast growth factor (FGF) signalling is dysregulated in multiple sclerosis (MS) and othe...
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. In around ...
Remyelination failure plays an important role in the pathophysiology of multiple sclerosis, but the ...
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervo...
Analysis of the effects of three members of the FGF family (FGF1, FGF2 and FGF9) and bone morphogeni...
Background/Aims: Huntington’s disease (HD) is a heritable neurodegenerative disorder, and there is n...
Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS l...
Fibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple scleros...
Fibroblast growth factor (FGF) signaling is involved in the pathogenesis of multiple sclerosis (MS)....
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous sy...
The role of the fibroblast growth factor (FGF) system in brain-related disorders has received consid...
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous sy...
Objective: Hippocampal insults have been observed in multiple sclerosis (MS) patients. Fibroblast g...
Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS l...
Fragile X syndrome (FXS) is the most common single-gene inherited form of intellectual disability, w...