Ependymoma (EPN) is a group of central nervous system tumors most commonly observed in young children. EPN is characterized by high intratumoral cellular heterogeneity meaning the cell population within a single tumor is extremely diverse, which makes understanding the disease more complex. Furthermore, different subtypes of EPN have been identified as more or less favorable in terms of prognosis. For example, posterior fossa group A (PF-A) and supratentorial EPN with ZFTA-RELA fusions (ST-RELA) have been identified as the more aggressive groups in young children. Mouse models have been established to further understand the cellular profile of human ependymoma tumors. Much of the existing data suggesting potential driver genes for EPN are d...
Ependymoma is the third commonest childhood brain tumour. Relapse is frequent, often fatal and curre...
Ependymoma (EPN) of childhood is curable in only 50% of cases, with recurrences in the remainder tha...
Item does not contain fulltextPURPOSE: To delineate clinically relevant molecular signatures of intr...
Ependymoma is a primary solid tumor of the central nervous system. Supratentorial ependymoma (ST-EPN...
We have previously shown immune gene phenotype variations between posterior fossa ependymoma subgrou...
Ozawa et al. present a murine tumor model resembling the most frequent molecular group of human supr...
Brain tumors are the leading cause of cancer death in children, with ependymoma being the third most...
Ependymomas exist within distinct genetic subgroups, but the molecular diversity within individual e...
Pediatric ependymomas are enigmatic tumors that continue to present a clinical management challenge ...
Cancers are characterized by non-random chromosome copy number alterations that presumably contain o...
Abstract Extensive molecular analyses of ependymal tumors have revealed that supratentorial and post...
Pediatric ependymomas are enigmatic tumors that continue to present a clinical management challenge ...
Genomic sequencing has driven precision-based oncology therapy; however, the genetic drivers of many...
BACKGROUND:: Ependymomas derive from ependymal cells that cover the cerebral ventricles and the cent...
Despite brain tumours being the leading cause of cancer death in children and ependymoma being the t...
Ependymoma is the third commonest childhood brain tumour. Relapse is frequent, often fatal and curre...
Ependymoma (EPN) of childhood is curable in only 50% of cases, with recurrences in the remainder tha...
Item does not contain fulltextPURPOSE: To delineate clinically relevant molecular signatures of intr...
Ependymoma is a primary solid tumor of the central nervous system. Supratentorial ependymoma (ST-EPN...
We have previously shown immune gene phenotype variations between posterior fossa ependymoma subgrou...
Ozawa et al. present a murine tumor model resembling the most frequent molecular group of human supr...
Brain tumors are the leading cause of cancer death in children, with ependymoma being the third most...
Ependymomas exist within distinct genetic subgroups, but the molecular diversity within individual e...
Pediatric ependymomas are enigmatic tumors that continue to present a clinical management challenge ...
Cancers are characterized by non-random chromosome copy number alterations that presumably contain o...
Abstract Extensive molecular analyses of ependymal tumors have revealed that supratentorial and post...
Pediatric ependymomas are enigmatic tumors that continue to present a clinical management challenge ...
Genomic sequencing has driven precision-based oncology therapy; however, the genetic drivers of many...
BACKGROUND:: Ependymomas derive from ependymal cells that cover the cerebral ventricles and the cent...
Despite brain tumours being the leading cause of cancer death in children and ependymoma being the t...
Ependymoma is the third commonest childhood brain tumour. Relapse is frequent, often fatal and curre...
Ependymoma (EPN) of childhood is curable in only 50% of cases, with recurrences in the remainder tha...
Item does not contain fulltextPURPOSE: To delineate clinically relevant molecular signatures of intr...